HomeDisease Specific InformationNon-Malignant/ Malignant Hematology Evaluation

Management of Non- malignant Hematology Issues

Oncology Nurse Practitioners are responsible for assisting in the diagnosis and management of different types of non- malignant hematology disorders. Blood disorders can affect white bloods cells, red blood cells causing anemia, and platelet dysfunction leading to bleeding problems. Other types of blood disorders involve abnormalities in the clotting system which can result in hypercoaguable and hpocoaguable states leading to increased risks of bleeding, blood clots, stroke, heart attacks, liver failure, and unexplained miscarriages in pregnant women. Oncology NPs may be required to perform bone marrow biopsies to aid in the diagnosis and treatment of these disorders.

Various non-malignant hematology disorders and resources for management include:

Anemias: There are many different causes of anemia. Some can be diagnosed by history and physical examination and reviewing the complete blood count results. Others are more complex and may involve extensive testing and possibly bone marrow biopsy to diagnose. Some are never definitively diagnosed. Briefly, the anemias fall into a few major categories. Some common causes of anemia include:

White Blood Cell Disorders
Neutropenia (too few bacteria-fighting white blood cells) Common causes for neutropenia include:

  • Neutrophilia (too many bacteria-fighting white blood cells) is usually due to an infection or inflammation but may result from not having a spleen or from having a myeloproliferative disorder which may become malignant.
  • Platelet Disorders
    • Thrombocytopenia (too few platelets resulting in coagulation problems).
    • Thrombocytosis (too many platelets) may result from infections or inflammation or from a myeloproliferative disorder.
    • Polycythemia vera is an overabundance of red bloods..
    • Iron Overload: Can be caused by genetic disorders such as primary or hereditary hemachromatosis. Secondary or acquired hemachromatosis can be caused by diseases such as thalassemia or sideroblastic anemia, chronic alcoholism, or other disorders. The frequent need for packed red blood cell transfusions can also cause iron overload.



Bone and Marrow Transplant SIG 

   Putting Evidence Into Practice: Prevention of Infection
   Creating a Palliative Educational Session for Hematopoietic Stem Cell Transplantation Recipients at Relapse 
   Fundamentals of Blood and Marrow Transplant Webcourse 
   National Guideline Clearinghouse 
   Guidelines for Treating Primary Hemochromatosis
   Treating Iron Overload in Patients with Hereditary Hemochromatosis
   MPN Connect
   Skyscape Medical Resources 
   Anticoagulation Advisor 
   Hematology Clinical Principles and Application, 4th Edition 
   Williams Hematology, 8th Edition 
   Hematology Basic Principles and Practice, 5th Edition 
   The Washington Manual of Hematology and Oncology Subspecialty Consult, 2nd Edition 
   Transfusion and Apheresis Science 
   Blood Transfusion Therapy: A Physician's Handbook 
   Cytogenetic Abnormalities in Hematologic Disorders
   Follow Up after Blood or Marrow Transplant (BMT): What now?